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Comparison of spectroscopically measured tissue alcohol concentration to blood and breath alcohol measurements

机译：光谱测量的组织酒精浓度与血液和呼吸酒精浓度的比较

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摘要

Alcohol testing is an expanding area of interest due to the impacts of alcohol abuse that extend well beyond drunk driving. However, existing approaches such as blood and urine assays are hampered in some testing environments by biohazard risks. A noninvasive, in vivo spectroscopic technique offers a promising alternative, as no body fluids are required. The purpose of this work is to report the results of a 36-subject clinical study designed to characterize tissue alcohol measured using near-infrared spectroscopy relative to venous blood, capillary blood, and breath alcohol. Comparison of blood and breath alcohol concentrations demonstrated significant differences in alcohol concentration [root mean square of 9.0 to 13.5 mg∕dL] that were attributable to both assay accuracy and precision as well as alcohol pharmacokinetics. A first-order kinetic model was used to estimate the contribution of alcohol pharmacokinetics to the differences in concentration observed between the blood, breath, and tissue assays. All pair-wise combinations of alcohol assays were investigated, and the fraction of the alcohol concentration variance explained by pharmacokinetics ranged from 41.0% to 83.5%. Accounting for pharmacokinetic concentration differences, the accuracy and precision of the spectroscopic tissue assay were found to be comparable to those of the blood and breath assays.
机译：由于酒精滥用的影响远远超出了酒后驾车，因此酒精检测是一个不断扩大的关注领域。但是，在某些测试环境中，现有的方法（例如血液和尿液分析）会受到生物危害风险的阻碍。由于不需要体液，因此无创的体内光谱技术提供了有希望的替代方法。这项工作的目的是报告一项针对36个主题的临床研究的结果，该研究旨在表征使用近红外光谱法测量的组织酒精相对于静脉血，毛细血管血和呼吸性酒精的特征。血液和呼吸中酒精浓度的比较表明，酒精浓度存在显着差异[均方根9.0至13.5 mg ∕ dL]，这归因于测定的准确性和精密度以及酒精的药代动力学。一阶动力学模型用于估计酒精药代动力学对血液，呼吸和组织检测之间观察到的浓度差异的贡献。研究了酒精测定法的所有成对组合，由药代动力学解释的酒精浓度变化的分数范围为41.0％至83.5％。考虑到药代动力学浓度的差异，发现光谱组织测定的准确性和精密度与血液和呼吸测定的准确性和精密度相当。

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